It is impossible to overstate the importance of James Watson’s contributions to science or the implications of his work for contemporary society. Throughout his life, Watson has continued his scientific work, from the laboratory at Cold Spring Harbor in New York. Not without controversy, he yet remains one of the most enduringly influential scientists alive. Targeting the big questions, writing the textbook that defined molecular biology, energizing the “war on cancer” and helping to map the human genome, he has served as a prime mover of the great biological revolution that affects us all. Decoding Watson is the first major biographical documentary on the life and work of this legendary figure in science and contemporary culture.